Self-regulation of the dopaminergic reward circuit in copyright users with mental imagery and neurofeedbackResearch in Context
Self-regulation of the dopaminergic reward circuit in copyright users with mental imagery and neurofeedbackResearch in Context
Blog Article
Background: Enhanced drug-related reward sensitivity accompanied by impaired sensitivity to non-drug related rewards in the mesolimbic dopamine system are thought to underlie the broad motivational deficits and dysfunctional decision-making frequently observed in spidertattooz.com copyright use disorder (CUD).Effective approaches to modify this imbalance and reinstate non-drug reward responsiveness are urgently needed.Here, we examined whether copyright users (CU) can use mental imagery of non-drug rewards to self-regulate the ventral tegmental area and substantia nigra (VTA/SN).We expected that obsessive and compulsive thoughts about copyright consumption would hamper the ability to self-regulate the VTA/SN activity and tested if real-time fMRI (rtfMRI) neurofeedback (NFB) can improve self-regulation of the VTA/SN.
Methods: Twenty-two CU and 28 healthy controls (HC) were asked to voluntarily up-regulate VTA/SN activity with non-drug reward imagery alone, or combined with rtfMRI NFB.Results: On a group level, HC and CU were able to activate the dopaminergic midbrain and other reward regions with reward imagery.In CU, the individual ability to self-regulate the VTA/SN was reduced in those with more severe obsessive-compulsive drug use.NFB enhanced the effect of reward imagery but did not result in transfer effects at the end of the session.
Conclusion: CU can voluntary activate their reward system with non-drug reward imagery and improve this ability with rtfMRI NFB.Combining mental imagery and rtFMRI NFB has great potential for acupatch modifying the maladapted reward sensitivity and reinstating non-drug reward responsiveness.This motivates further work to examine the use of rtfMRI NFB in the treatment of CUD.Keywords: copyright use disorder, Dopamine, Mental imagery, Neurofeedback, Real-time fMRI, Reward sensitivity, Treatment.